Trapped in their New York brownstone’s panic room, a hidden chamber built as a sanctuary in the event of break-ins, newly divorced Meg Altman and her young daughter Sarah play a deadly game of cat-and-mouse with three intruders – Burnham, Raoul and Junior – during a brutal home invasion. But the room itself is the focal point because what the intruders really want is inside it.
When a promised job for Texan Michael fails to materialise in Wyoming, Mike is mistaken by Wayne to be the hitman he hired to kill his unfaithful wife, Suzanne. Mike takes full advantage of the situation, collects the money and runs. During his getaway, things go wrong, and soon get worse when he runs into the real hitman, Lyle.
Recently promoted and transferred to the homicide division, Inspector Jessica Shepard feels pressure to prove herself — and what better way than by solving San Francisco’s latest murder? However, as Shepard and her partner, Mike Delmarco, soon discover, the victim shared a romantic connection to her. As more of Shepard’s ex-lovers turn up dead, her mind starts to become unstable, and she begins to wonder if she could be the very killer she’s trying to track down.